@article{87861,
  keywords = {Humans, phosphorylation, Models, Biological, Homocysteine, Alzheimer Disease, Risk Factors, Methylation, Protein Phosphatase 2, Phosphoprotein Phosphatases, tau Proteins},
  author = {Scott Vafai and Jeffry Stock},
  title = {Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer{\textquoteright}s Disease.},
  abstract = { Tau hyperphosphorylation is a central event in the development of Alzheimer{\textquoteright}s Disease (AD). Protein phosphatase 2A (PP2A) heterotrimer formation is necessary for efficient dephosphorylation of the tau protein. S-Adenosylmethionine-dependent carboxyl methylation is essential for the assembly of PP2A heterotrimers. Epidemiological evidence indicates that elevated plasma homocysteine is an independent risk factor for AD. Homocysteine is a key intermediate in the methyl cycle and elevated plasma homocysteine results in a global decrease in cellular methylation. We propose that the PP2A methylation system is the link relating elevated plasma homocysteine to AD. },
  year = {2002},
  journal = {FEBS Lett},
  volume = {518},
  pages = {1-4},
  month = {05/2002},
  issn = {0014-5793},
  language = {eng},
}